Trigger, also refered as "Weak Quirk Improvement Drug, is a type of drug that gives a boost to a individual's Quirk, simutaneously weakening their sense of reason. Trigger addicts suffer a side-effect after the use that changes their tongues color to black.
- An unnamed villain from Chapter 133, whose Blade was amplified to a such a level that he sprouted great number of very long blades from his body. He was capable of controlling them, sprouting and retracting them, as well as focusing them in one place to reach great destructive power. They became sharp enough to nick Kirishima's Hardening.
- Raputo Tokage, whose lizard appearance was amplified to a strong Pterodon Physiology Quirk.
- Moyuru Touchi, who only appeared to have a small flame in place of his hair , was amplified to become a powerful flaming rock golem.
- Souga Kugizaki, whose Spikes was amplified to a Porcupine Physiology Quirk, that made stronger spikes grow all over his body.
- An unnamed salesman from Chapter 2 (Illegals), whose unrevealed Quirk was amplified to transform him into a massive four-armed giant.
- Akira Iwakou, whose Quirk was amplified to a Hardening transformation-type Quirk, with additional Enlargement and Super Strength abilities.
- Teruo Unagisawa, whose unrevealed Quirk was amplified to make him a large, eel-like creature, whose skin was capable of secreting slippery slime. He also had greatly enhanced mobility, being able to bounce off the walls of buildings to launch himself into the air and even keep up with Pop Step's Bound. His mouth was also filled with numerous sharp teeth, somewhat resembling a leech.
- An unnamed civilian from Chapter 5 (Illegals), who was amplified to gain blades on his fingers and shoulders, as well as Muscle Enhancement and Enlargement.
- An unnamed civilian from Chapter 5 (Illegals), who was amplified to release electricity from her eyes.
- An unnamed civilian from Chapter 5 (Illegals), who was amplified to release black fluid from his palms.
- An unnamed civilian from Chapter 5 (Illegals), who was amplified to catch on fire.
- An unnamed civilian from Chapter 5 (Illegals), who was amplified to become very large and round, with dark skin and lighter markings. His body also released streams of water from several points.